{"id":16918,"date":"2026-08-01T14:29:29","date_gmt":"2026-08-01T12:29:29","guid":{"rendered":"https:\/\/abrelosojos.vision\/evidence\/"},"modified":"2026-10-01T22:47:27","modified_gmt":"2026-10-01T20:47:27","slug":"evidence","status":"publish","type":"page","link":"https:\/\/abrelosojos.vision\/en\/evidence\/","title":{"rendered":"What we know. What we do not."},"content":{"rendered":"[vc_row type=&#8221;full_width_background&#8221; full_screen_row_position=&#8221;middle&#8221; bg_color=&#8221;#f4f3ef&#8221; text_color=&#8221;dark&#8221; id=&#8221;start&#8221; class=&#8221;alo-page alo-editorial alo-evidence-hero alo-evidence-v3&#8243; row_name=&#8221;ALO \u00b7 EVIDENCE \u00b7 LIMIT&#8221;]\n[vc_column width=&#8221;7\/12&#8243; el_class=&#8221;alo-prose&#8221;]\n[vc_column_text]\n<h6>EVIDENCE AND LIMITS<\/h6>\n<h1>What we know. What we do not.<\/h1>\n<p class=\"alo-lead\">When they stop or cut back, some people notice changes in sleep, appetite, mood or cravings. Research offers ranges, not a prediction about you.<\/p>\n<p class=\"alo-evidence-hero__actions\"><a class=\"alo-evidence-primary\" href=\"#short-answer\">Read the short answer <span aria-hidden=\"true\">\u2193<\/span><\/a><a href=\"#sources\">Open the sources <span aria-hidden=\"true\">\u2192<\/span><\/a><\/p>\n[\/vc_column_text]\n[\/vc_column]\n[vc_column width=&#8221;5\/12&#8243; el_class=&#8221;alo-prose&#8221;]\n[vc_column_text]\n<aside class=\"alo-evidence-stamp\">\n<p>21 days are not a magic date.<\/p>\n<p><span>They are a practical window for observing your nights, your rest and your decisions.<\/span><\/aside>\n[\/vc_column_text]\n[\/vc_column]\n[\/vc_row]\n[vc_row type=&#8221;full_width_background&#8221; full_screen_row_position=&#8221;middle&#8221; bg_color=&#8221;#fcfbf8&#8243; text_color=&#8221;dark&#8221; id=&#8221;short-answer&#8221; class=&#8221;alo-page alo-editorial alo-evidence-brief&#8221; row_name=&#8221;ALO \u00b7 EVIDENCE \u00b7 SHORT ANSWER&#8221;]\n[vc_column width=&#8221;1\/1&#8243;]\n[vc_column_text]\n<header class=\"alo-evidence-section-head\">\n<h6>THE SHORT ANSWER<\/h6>\n<h2>Quite a lot may shift. There is no script for you.<\/h2>\n<\/header>\n<div class=\"alo-evidence-brief-list\">\n<article><span>01<\/span><\/p>\n<div>\n<h3>Withdrawal may occur.<\/h3>\n<p>One review estimates it in around half of people who use cannabis regularly or are dependent on it. Changes in sleep, irritability, anxiety, mood and appetite are among the most common.<\/p>\n<\/div>\n<\/article>\n<article><span>02<\/span><\/p>\n<div>\n<h3>It often starts early. It does not run to a clock.<\/h3>\n<p>Clinical literature describes a common onset within 24 to 48 hours and greater intensity between days 2 and 6. These are group ranges, not a timetable for your body.<\/p>\n<\/div>\n<\/article>\n<article><span>03<\/span><\/p>\n<div>\n<h3>21 days do not reset the body.<\/h3>\n<p>At ALO they are a practical window for moving through repeated scenes and observing. They are not a medical deadline, a THC cleanse or the date when a habit disappears.<\/p>\n<\/div>\n<\/article>\n<\/div>\n<p class=\"alo-evidence-brief__limit\"><strong>ALO&#8217;s limit:<\/strong> it offers educational and practical support. It is not treatment and has not been tested as a clinical intervention.<\/p>\n[\/vc_column_text]\n[\/vc_column]\n[\/vc_row]\n[vc_row type=&#8221;full_width_background&#8221; full_screen_row_position=&#8221;middle&#8221; bg_color=&#8221;#ebe7df&#8221; text_color=&#8221;dark&#8221; id=&#8221;tonight&#8221; class=&#8221;alo-page alo-editorial alo-evidence-action&#8221; row_name=&#8221;ALO \u00b7 EVIDENCE \u00b7 WHAT TO DO&#8221;]\n[vc_column width=&#8221;7\/12&#8243; el_class=&#8221;alo-prose&#8221;]\n[vc_column_text]\n<h6>WHAT TO DO WITH THIS<\/h6>\n<h2>Three clues. A little more room.<\/h2>\n<p class=\"alo-lead\">Choose a moment that repeats and look at it with curiosity, not to monitor yourself. It is enough to note something you will recognize tomorrow.<\/p>\n<dl class=\"alo-evidence-observation\">\n<div>\n<dt>When does it appear?<\/dt>\n<dd>Time, place and company.<\/dd>\n<\/div>\n<div>\n<dt>What did it promise to solve?<\/dt>\n<dd>Sleep, reward, a break, boredom or something else.<\/dd>\n<\/div>\n<div>\n<dt>What will you prepare?<\/dt>\n<dd>One small move to give yourself room when the scene arrives.<\/dd>\n<\/div>\n<\/dl>\n<nav class=\"alo-evidence-practical-links\" aria-label=\"Resources for tonight\"><a href=\"https:\/\/abrelosojos.vision\/en\/sleep-without-weed\/\">Prepare for tonight <span aria-hidden=\"true\">\u2192<\/span><\/a><a href=\"https:\/\/abrelosojos.vision\/en\/weed-cravings\/\">Buy ten minutes <span aria-hidden=\"true\">\u2192<\/span><\/a><a href=\"https:\/\/abrelosojos.vision\/en\/anxiety-when-stopping-weed\/\">Know when to seek other help <span aria-hidden=\"true\">\u2192<\/span><\/a><\/nav>\n[\/vc_column_text]\n[\/vc_column]\n[vc_column width=&#8221;5\/12&#8243; el_class=&#8221;alo-prose&#8221;]\n[vc_column_text]\n<aside class=\"alo-evidence-safety\">\n<h3>If this needs more support.<\/h3>\n<p>Some situations deserve professional or immediate help: if there is danger, severe symptoms, polydrug use that concerns you or you do not feel safe.<\/p>\n<p>Asking for help does not invalidate the break or mean that you are doing it wrong. Looking after yourself comes first.<\/p>\n<p><a href=\"https:\/\/abrelosojos.vision\/en\/cannabis-guides-and-help\/#help\">Find other help <span aria-hidden=\"true\">\u2192<\/span><\/a><\/p>\n<\/aside>\n[\/vc_column_text]\n[\/vc_column]\n[\/vc_row]\n[vc_row type=&#8221;full_width_background&#8221; full_screen_row_position=&#8221;middle&#8221; bg_color=&#8221;#f4f3ef&#8221; text_color=&#8221;dark&#8221; id=&#8221;sources&#8221; class=&#8221;alo-page alo-editorial alo-evidence-sources-v3&#8243; row_name=&#8221;ALO \u00b7 EVIDENCE \u00b7 SOURCES AND SCOPE&#8221;]\n[vc_column width=&#8221;1\/1&#8243;]\n[vc_column_text]\n<span id=\"method\" class=\"alo-section-anchor\" data-alo-evidence-method-anchor=\"1.0.0\" aria-hidden=\"true\"><\/span><\/p>\n<header class=\"alo-evidence-section-head\">\n<h6>SOURCES AND SCOPE \u00b7 REVIEWED 30 AUGUST 2026<\/h6>\n<h2>Open the source. See what holds up.<\/h2>\n<p class=\"lead\">A group statistic does not predict an individual story. And a comparable guide does not show that ALO produces those results.<\/p>\n<\/header>\n<ol class=\"alo-evidence-source-list\">\n<li><span>01<\/span>\n<div>\n<h3>Withdrawal after stopping or substantially reducing use.<\/h3>\n<p><strong>Studies:<\/strong> clinical literature on regular or dependent use.<\/p>\n<p><strong>Supports saying:<\/strong> withdrawal may occur; onset and intensity tend to fall within population ranges.<\/p>\n<p><strong>Does not show:<\/strong> what will happen to you or how long it will last.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34791767\/\" rel=\"noopener noreferrer\" target=\"_blank\">Connor and colleagues <span aria-hidden=\"true\">\u2197\ufe0e<\/span><\/a><\/div>\n<\/li>\n<li><span>02<\/span>\n<div>\n<h3>A 21-day guide \u00b7 not ALO.<\/h3>\n<p><strong>Studies:<\/strong> a pilot involving 125 young adults aged 18 to 29.<\/p>\n<p><strong>Supports saying:<\/strong> 84% of those who reported using the guide a lot completed the break, compared with 57% of those who did not use it.<\/p>\n<p><strong>Does not show:<\/strong> causality or ALO&#8217;s effectiveness. There was no random assignment or assigned control group; use was voluntary.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36595624\/\" rel=\"noopener noreferrer\" target=\"_blank\">Fontana and colleagues <span aria-hidden=\"true\">\u2197\ufe0e<\/span><\/a><\/div>\n<\/li>\n<li><span>03<\/span>\n<div>\n<h3>CB1 receptors during monitored abstinence.<\/h3>\n<p><strong>Studies:<\/strong> a small, specific sample of chronic daily cannabis users using PET.<\/p>\n<p><strong>Supports saying:<\/strong> reversible biological adaptations were observed in that sample.<\/p>\n<p><strong>Does not show:<\/strong> a bodily \u201creset\u201d in 21 days or a universal timetable.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21747398\/\" rel=\"noopener noreferrer\" target=\"_blank\">Hirvonen and colleagues <span aria-hidden=\"true\">\u2197\ufe0e<\/span><\/a><\/div>\n<\/li>\n<li><span>04<\/span>\n<div>\n<h3>Early changes in CB1 availability.<\/h3>\n<p><strong>Studies:<\/strong> 11 men with cannabis dependence and 19 controls, with monitored abstinence.<\/p>\n<p><strong>Supports saying:<\/strong> some changes began early in that sample.<\/p>\n<p><strong>Does not show:<\/strong> that the whole body returns to normal, that the same occurs in other populations or that ALO produces the change.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29560896\/\" rel=\"noopener noreferrer\" target=\"_blank\">D\u2019Souza and colleagues <span aria-hidden=\"true\">\u2197\ufe0e<\/span><\/a><\/div>\n<\/li>\n<\/ol>\n<aside class=\"alo-evidence-method-note\">\n<h3>How we use a source.<\/h3>\n<ul>\n<li>We say who was studied.<\/li>\n<li>We separate association from causality.<\/li>\n<li>We correct or remove what does not hold up.<\/li>\n<\/ul>\n<\/aside>\n[\/vc_column_text]\n[\/vc_column]\n[\/vc_row]\n[vc_row type=&#8221;full_width_background&#8221; full_screen_row_position=&#8221;middle&#8221; bg_color=&#8221;#2b2c30&#8243; text_color=&#8221;light&#8221; class=&#8221;alo-page alo-editorial alo-evidence-contract&#8221; row_name=&#8221;ALO \u00b7 EVIDENCE \u00b7 ALO&#8217;S CONTRACT&#8221;]\n[vc_column width=&#8221;7\/12&#8243; el_class=&#8221;alo-prose&#8221;]\n[vc_column_text]\n<h6>WHAT ALO CAN TAKE CARE OF<\/h6>\n<h2>One useful email. One action. One person if you write.<\/h2>\n<p class=\"alo-lead\">For 21 days you receive a brief perspective and something specific you can try. My ALO keeps the thread only if it helps; it does not create streaks or tasks.<\/p>\n<p>That is something we can deliver and check. The conclusion comes from what you observe.<\/p>\n[\/vc_column_text]\n[\/vc_column]\n[vc_column width=&#8221;5\/12&#8243; el_class=&#8221;alo-prose&#8221;]\n[vc_column_text]\n<h3>What we cannot know for you.<\/h3>\n<p>We cannot know in advance what you will feel or promise a cure, easy withdrawal or that you will use less afterwards. We can support you clearly and without judgement, without asking you to decide forever.<\/p>\n<div class=\"alo-contact-door-inline\">\n<p>A missing source, a question or something you disagree with? You don\u2019t need to build a case before writing.<\/p>\n<p><a href=\"https:\/\/abrelosojos.vision\/en\/contact\/\">Leave a question or an objection <span aria-hidden=\"true\">\u2192<\/span><\/a><\/p>\n<\/div>\n<p class=\"alo-evidence-contract__meta\"><a href=\"https:\/\/abrelosojos.vision\/en\/privacy-policy\/\">How we handle data<\/a> \u00b7 <a href=\"https:\/\/abrelosojos.vision\/en\/who-is-behind-alo\/\">Who signs this<\/a><\/p>\n<p class=\"alo-evidence-contract__decision\"><strong>21 days without weed \u00b7 EUR 49 \u00b7 One payment \u00b7 No renewal<\/strong><\/p>\n[\/vc_column_text][nectar_btn size=&#8221;large&#8221; open_new_tab=&#8221;false&#8221; button_style=&#8221;see-through-2&#8243; color_override=&#8221;#fcfbf8&#8243; hover_color_override=&#8221;#8d6878&#8243; hover_text_color_override=&#8221;#fcfbf8&#8243; text=&#8221;See how the trial starts&#8221; url=&#8221;\/en\/start\/&#8221;]\n[\/vc_column]\n[\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>[vc_row type=&#8221;full_width_background&#8221; full_screen_row_position=&#8221;middle&#8221; bg_color=&#8221;#f4f3ef&#8221; text_color=&#8221;dark&#8221; id=&#8221;start&#8221; class=&#8221;alo-page alo-editorial alo-evidence-hero alo-evidence-v3&#8243;&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16918","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/abrelosojos.vision\/en\/wp-json\/wp\/v2\/pages\/16918","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/abrelosojos.vision\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/abrelosojos.vision\/en\/wp-json\/wp\/v2\/types\/page"}],"replies":[{"embeddable":true,"href":"https:\/\/abrelosojos.vision\/en\/wp-json\/wp\/v2\/comments?post=16918"}],"version-history":[{"count":2,"href":"https:\/\/abrelosojos.vision\/en\/wp-json\/wp\/v2\/pages\/16918\/revisions"}],"predecessor-version":[{"id":17222,"href":"https:\/\/abrelosojos.vision\/en\/wp-json\/wp\/v2\/pages\/16918\/revisions\/17222"}],"wp:attachment":[{"href":"https:\/\/abrelosojos.vision\/en\/wp-json\/wp\/v2\/media?parent=16918"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}